I have came across this life changing speech by Carnegie Mellon's professor Randy Pausch before he passed away after battled with pancreatic cancer. Spare an hour and 15 mins in your busy life if you could to listen to this speech. What is really matter in your life!? Haven't listened to anything affects me this much for a very long long time. Very moving and inspirational.
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Video: http://www.youtube.com/watch?v=ji5_MqicxSo